What is Glutamine Transaminase?
Glutamine is an essential protein building block. It also helps make other amino acids and removes waste products, like ammonia, from your body. It plays a key role in chemical (metabolic) processes that provide your body with the energy it needs to work.
Glutamine is the most abundant amino acid in the body, crucial for producing protein, supporting immune function, maintaining gut health, and fueling cells during stress, injury, or severe illness. It supports intestinal barrier integrity, helps heal tissues after surgery or cancer treatment, and aids in muscle recovery, often acting as a "conditionally essential" nutrient.
Everything You Need to Know
Can you take L-glutamine while on chemotherapy?
Therefore, use of glutamine should only be done under the guidance of a trusted integrative oncology provider during active cancer treatment. Glutamine should not be taken during paclitaxel (Taxol and Abraxane) and docetaxel (Taxotere) chemotherapy as it may increase the risk of peripheral neuropathy.
What is the downside of glutamine?
Health care providers must know that consumption of dietary supplements such as glutamine may be associated with serious side effects. Liver damage is a possible side effect of glutamine. Hence it is necessary to consider hepatotoxicity as an adverse reaction in case of glutamine supplement consumption.
Who should avoid glutamine?
Individuals with kidney disease, liver disease, or Reye's syndrome should avoid L-glutamine supplements, as they can worsen these conditions. Those with cancer, epilepsy, bipolar disorder, or severe sensitivity to MSG should also avoid it or consult a doctor due to risks of accelerating tumor growth, triggering seizures, or causing mania.
Which cancers feed on glutamine?
Mutations in the K-RAS oncogene are commonly found in pancreatic, colorectal, and lung cancers, where it has been shown to regulate glutamine uptake (glutamine addiction) and subsequent utilization of anabolic processes unfolding non-canonical pathways crucial for sustaining rapid tumor cell proliferation and growth
Main Details:
Gut Health & Integrity: Glutamine is a primary energy source for intestinal cells and helps maintain the intestinal mucosal barrier, preventing "leaky gut" and reducing inflammation.
Immune System Support: It serves as fuel for immune cells, including macrophages, T-cells, and B-cells, aiding in infection control and managing inflammatory responses.
Tissue Repair and Healing: Known for aiding recovery after injuries, surgeries, or chemotherapy by enhancing cell proliferation and reducing inflammation.
Muscle Protein Synthesis: While the body makes it, high-intensity exercise can deplete glutamine levels. It is vital for protein synthesis and can aid in glycogen replenishment, reducing muscle soreness.
Nutritional Support for Serious Illness: Used alongside specific treatments to treat conditions like short bowel syndrome, severe burns, and to help with chemotherapy-induced neuropathy or diarrhea.
The glutamine your body makes plays such an important role in maintaining your overall health that scientists are studying the potential benefits of taking glutamine supplements. For the most part, though, research shows that healthy people don't need to take glutamine. Healthy bodies do a good job of making enough glutamine and getting it from a regular diet.
Some research suggests that taking glutamine can provide benefits in treating some conditions - although the evidence can be unclear. In most cases, more research is needed to understand any potential benefits of taking glutamine.
ANALYTICAL RESULTS
| Test Item | Method / Ref. | Specification | Result | Conclusion |
|---|---|---|---|---|
| Identification | In-house ID / label claim | Transglutaminase / "Glutamine Transaminase" | Conforms | Pass |
| Appearance | Visual | White to off-white powder | White powder | Pass |
| Odor | Organoleptic | Characteristic | Conforms | Pass |
| Enzyme Activity | Hydroxamate method / supplier method | 90–120 U/g | 104 U/g | Pass |
| Mesh Size / Sieve | Sieve | NLT 98.5% through 60 mesh | Conforms | Pass |
| Loss on Drying | Gravimetric | ≤ 8.0% | 4.6% | Pass |
| Lead (Pb) | ICP-MS / ICP-OES | ≤ 2.0 mg/kg | 0.18 mg/kg | Pass |
| Arsenic (As) | ICP-MS / ICP-OES | ≤ 2.0 mg/kg | 0.10 mg/kg | Pass |
| Total Plate Count | Plate count | < 5,000 CFU/g | 9.0 × 10² CFU/g | Pass |
| E. coli | Absence test | Negative | Not Detected | Pass |
| Salmonella | Absence test | None detected in 10 g | Not Detected | Pass |
Production Process
