Nattokinase is a natural part of a Japanese soy food called natto. As medicine, nattokinase has most often been used by adults in doses of 2000-7000 fibrinolytic units by mouth daily for up to 3 years. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Everything You Need to Know
What are the negative side effects of nattokinase?
Severe bleeding and bruising: Nattokinase may weaken your blood by breaking clots. For this reason, there's a chance of severe bleeding and bruising side effects.
Who cannot take nattokinase?
Do Not Take if: You have coagulation disorders or are currently using an anticoagulant drug. You take aspirin daily: Nattokinase may increase its effects and lead to excessive bleeding.
Is nattokinase hard on the liver?
The results showed that NK improved liver functions, impaired oxidative status, the cholinergic deficits, and minified the misfolded proteins aggregates.
Is nattokinase better than statins?
Compared with traditional lipid-lowering drugs (e.g., statins and fibrates), nattokinase has a multifaceted lipid-lowering mechanism and lower risk of side effects, which makes it suitable for patients intolerant of traditional drugs; when combined with natural products such as statins, fibrates, red yeast, and ...
Main Details:
To prevent blood clots
Preliminary studies suggest that nattokinase may prevent deep vein thrombosis.
To reduce high blood pressure
Preliminary studies suggest nattokinase may lower blood pressure.
Alzheimer's disease
Although animal models suggest nattokinase may degrade amyloid plaques, human studies have not been conducted.
Cancer treatment
Although nattokinase is promoted as an alternative cancer treatment, clinical data of its effectiveness are lacking.
There is interest in using nattokinase for its cardiovascular benefits such as reducing blood clotting and lowering blood pressure.However, nattokinase does not seem to lower cholesterol nor reduce atherosclerosis. In a randomized trial in 265 adults with an average age of 65 years, taking 100 mg (2,000 fibrinolytic units (FU)) of nattokinase daily for about 3 years did not slow the progression of atherosclerosis compared to a placebo.The same dose taken for 6 months also did not lower cholesterol levels compared to a placebo,except when it was used in combination with red yeast rice, which is a natural source for the cholesterol-lowering drug lovastatin.Some researchers insist that higher doses of nattokinase may have a benefit for cholesterol. In fact, one large observational study in Chinese patients found that taking 10,800 FU of nattokinase daily for a year was associated with a reduction in cholesterol, while a lower dose of 3,600 FU daily was not associated with a reduction in cholesterol.This observational study cannot show cause and effect, so further interventional research is needed. It's unclear if these effects are generalizable to other geographic locations.
ANALYTICAL RESULTS
| Test Item | Method / Ref. | Specification | Result | Conclusion |
|---|---|---|---|---|
| Identification | In-house ID / label claim | Nattokinase | Conforms | Pass |
| Appearance | Visual | White to off-white powder | Off-white powder | Pass |
| Nattokinase Activity | Fibrinolytic activity assay / supplier method | NLT 20,000 FU/g | 21,850 FU/g | Pass |
| Activity Unit | Supplier-defined fibrin degradation unit | Report only | FU/g | Pass |
| Odor & Taste | Organoleptic | Slight fermentation odor, no off-odor | Conforms | Pass |
| Loss on Drying | Gravimetric | ≤ 10.0% | 4.8% | Pass |
| Particle Size | Sieve | NLT 95% through 80 mesh | Conforms | Pass |
| Lead (Pb) | ICP-MS / ICP-OES | ≤ 3.0 ppm | 0.24 ppm | Pass |
| Arsenic (As) | ICP-MS / ICP-OES | ≤ 1.0 ppm | 0.10 ppm | Pass |
| Cadmium (Cd) | ICP-MS / ICP-OES | ≤ 1.0 ppm | < 0.05 ppm | Pass |
| Mercury (Hg) | ICP-MS / ICP-OES | ≤ 0.1 ppm | < 0.01 ppm | Pass |
| Total Plate Count | Plate count | ≤ 3,000 CFU/g | 8.0 × 10² CFU/g | Pass |
| Yeast & Mold | Plate count | ≤ 100 CFU/g | < 10 CFU/g | Pass |
| Coliforms | Plate count | ≤ 30 CFU/g | < 10 CFU/g | Pass |
| E. coli | Absence test | Negative / 25 g | Not Detected | Pass |
| Salmonella | Absence test | Negative / 25 g | Not Detected | Pass |
Production Process
