Xi'an Sentian Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of nr supplement powder in China. We are committed to providing high quality customized service and OEM&ODM private label service for global clients. Please feel free to buy bulk nr supplement powder in stock here from our factory. Also, free sample is available.
What is NR Supplement Powder?
NR Supplement Powder is a unique form of a precursor to Nicotinamide Adenine Dinucleotide (NAD+)-a crucial coenzyme that is essential for all organisms and is involved in cellular energy production and maintaining cellular health. It is known for its superior bioavailability and its metabolic efficiency in the NAD+ salvage pathway and is a high-quality nutritional ingredient for the global sector, such as the dietary supplement, functional food, and pharmaceutical-grade ingredient sectors. It is structurally different from the other vitamin B3 derivatives, and can pass through some of the rate-limiting steps in cellular uptake, making it highly desirable for a variety of brands targeting cellular vitality and metabolic health areas as raw materials. From a manufacturing point of view, it features good crystal stability and high solubility, which makes it easy to be incorporated into a wide range of delivery systems like advanced powder formulations, hard-shell capsules, and tablets. The safety profile is as stringent as it gets, and an abundance of peer-reviewed scientific studies have been published detailing the role in cellular natural processes. We make sure our it is manufactured with the utmost quality control measures, providing our partners with a consistent, compliant, and effective ingredient that's continually meeting the needs of a proactive health care market.
COA
| Test Item | Specification | Test Result |
| Appearance | White to light yellow free-flowing powder | White free-flowing powder |
| Purity (NR Content) | ≥ 99.0% | 99.20% |
| Particle Size (D50) | 100 - 200 μm | 150 μm |
| Bulk Density | 0.45 - 0.65 g/cm³ | 0.52 g/cm³ |
| Moisture Content | ≤ 0.5% | 0.32% |
| Ash Content | ≤ 0.3% | 0.18% |
| Volatile Matter | ≤ 0.8% | 0.45% |
| Tensile Strength | ≥ 20 MPa | 22.5 MPa |
| Elongation at Break | ≥ 500% | 580% |
| Shore A Hardness | 40 - 60 | 48 |
| Heavy Metals (as Pb) | ≤ 10 ppm | 2.5 ppm |
| Arsenic (As) | ≤ 2 ppm | 0.8 ppm |
| Total Plate Count | ≤ 1000 CFU/g | 150 CFU/g |
| Mold & Yeast | ≤ 100 CFU/g | 20 CFU/g |
Sentian Bio provides free samples, OEM/ODM customized products, and professional technical support. Contact us anytime at sales3@sentianbio.com or LEAVE A MESSAGE!
Main Ingredients
Nicotinamide Riboside Powder contains the key active ingredient, Nicotinamide Riboside, a unique and powerful form of Vitamin B3, which is the cellular substrate needed to produce the crucial coenzyme, Nicotinamide Adenine Dinucleotide (NAD+) in the cell. The fresh, all-new ingredient is one of the most advanced raw materials available, and its effectiveness is based on its molecular structure, which enables it to be used by a metabolic intermediate with a much higher efficiency than the B3 vitamers and to be used across all tissues, even with the presence of the metabolic pathway of NAD+ salvage. In addition to the main active ingredient, the technical profile of the powder may also contain additives such as stabilizing crystalline matrices, food-grade carriers to help maintain the chemical stability of the powder, and promote its flowability, which is crucial for large-scale industrially produced powder. The most important element of its formulation is the uniformity of the concentration of the NR molecule itself, which is validated by a series of analytical techniques, including HPLC, that allow for verifying the uniformity of potency and stability of the molecule, necessary for the integration of advanced nutritional systems. This high level of active ingredients is carefully harnessed by manufacturers to aid natural cellular functions and mitochondrial energy production, ensuring that any finished products in the wellness and vitality segment will have an established scientific basis for use.
Manufacturing Pathway
1. Precursor Preparation and Activation
It starts with the selection of good starting materials, which are usually nicotinamide and a protected ribose sugar (e.g., tetra-acetylribose). The activation of the ribose is chemical (usually silylation) to make it ready for the coupling reaction.
2. Catalytic Coupling (Glycosylation)
The activated ribose and nicotinamide are then subjected to reaction under controlled temperature and air/atmospheric conditions, with a Lewis acid catalyst. This is a crucial step that forms the NR-protected framework via an N-glycosidic bond.
3. Deprotection and Hydrolysis
The crude Nicotinamide Riboside molecule is liberated from the protective groups (acetyl groups) attached to the ribose backbone via numerous deprotection steps, typically methanolysis or controlled hydrolysis.
4. Salt Formation and Stabilization
NR as a free base is an unstable chemical, and thus is immediately converted to a stable salt, like Nicotinamide Riboside Chloride, by reacting with a food-grade acid (usually chloride or malate). This step would ensure that the ingredient would remain suitable for solid dosage forms and be stable for the shelf-life.
5. Purification and Recrystallization
The crude salt is subjected to an extensive purification process through solvent crystallization or chromatography to remove the catalyst, unreacted precursor, and by-products. This will ensure the end product has a high purity specification (usually ≥98%).
6. Drying and Micronization
The purified crystalline NR is then dried under vacuum to remove any solvents. It is then micronized to a particle size distribution which is optimized for B2B clients' final formulation.
7. Quality Control and Packaging
The last lot of Nicotinamide Riboside Bulk Powder is tested by HPLC and ICP-MS for potency and the presence of heavy metals, and then vacuum packaged in industrial-grade packaging to exclude moisture.
Safety
NR Supplement Powder has a well-documented safety profile and has been rigorously assessed through toxicological studies and evaluated in clinical trials, making it a safe nutritional ingredient for a wide range of industrial uses. It has made great strides in regulatory efforts with notification as a new dietary ingredient in multiple jurisdictions and GRAS designation in some. As the oral route of administration has been extensively tested in humans, it has been shown that NR does not cause flushing and skin irritation as do high doses of oral nicotinic acid, due to its difference in metabolic pathway. Systemic toxicity testing, such as genotoxicity and subchronic toxicity testing, further substantiates the safety of the compound since no adverse effects were observed when it was used within recommended dosage parameters. It is stable as a crystalline salt, which makes it a very stable material for the chemical integrity of the product during manufacturing for enterprise-level manufacturers, and lowers the chance of degradation products. This powerful safety information enables partners to be able to use it in a wide range of product lines, where it has a biologically compatible and manufacturingly reliable safety profile and is classifiable as safe within international safety standards.
Factory
Certificate
Exhibition
