L-5 Methyltetrahydrofolate Calcium Powder

L-5 Methyltetrahydrofolate Calcium Powder

Product Name: L-5 Methyltetrahydrofolate Calcium Powder / Calcium L-5-MTHF Powder
CAS No.: 151533-22-1
Purity: 99% L-5-MTHF Calcium (HPLC)
Appearance: Light Yellow to Yellow Fine Powder
Grade: Food Grade / Supplement Grade / Pharmaceutical Grade
Certificates: GMP, ISO, HACCP, Kosher, Halal, FDA
MOQ: 1kg for Sample Order / Bulk Order Available
OEM & ODM Service: Capsules, Tablets, Sachets Available
Packaging: 1kg Aluminum Foil Bag / 25kg Drum / Customized Packaging
Documents: COA, MSDS, TDS Available
Sample: Free Sample Available
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Description
Technical Parameters

What is L-5 Methyltetrahydrofolate Calcium Powder?

 

L-5-Methyltetrahydrofolate Calcium Powder is the calcium salt form of L-5-methyltetrahydrofolate, which is a biologically active ingredient of folate that is extensively applied as a raw material in the food, beverage, and nutrition formulation industry. It is a highly purified, crystalline powder that is intended for use in a manufacturing area that requires a stable and ready-to-use source of folate. The naturally occurring and metabolically active form of folate, L-5-Methyltetrahydrofolate (5-MTHF), and its conversion to a calcium salt will enhance its handling characteristics, thermal stability, and compatibility in industry processing systems. The powder form is good in terms of solubility and dispersibility, and can be added to capsules, tablets, powder blends, premixes, and fortified food systems. While still offering the same benefits as synthetic forms of folic acid, 5-MTHF calcium offers a new ingredient choice that can be utilized more seamlessly in formulation processes, as it does not need to be converted to folic acid during the formulation process. It is widely employed in the production of nutritional products, functional food fortification, beverage enrichment systems, and multi-ingredient premix solutions. It has consistently high assay, controlled particle size distribution, and is reliable in production at high speed. It is also easy to accommodate various excipients and actives for flexible formulation design in various product categories, which is another advantage for manufacturers.

 

L-5 Methyltetrahydrofolate Calcium Powder

 

COA

 

Analysis Item Specification Result Test Method
Appearance White to light yellow or beige powder White powder Visual
Identification HPLC Retention time corresponds to standard Complies HPLC
Assay (Dry basis) 95.0% ~ 102.0% 99.20% HPLC
D-5-Methyltetrahydrofolate ≤ 1.0% 0.30% HPLC
Specific Optical Rotation +16.0° ~ +20.0° +18.2° USP <781>
Water Content 5.0% ~ 17.0% 11.50% Karl Fischer
Calcium Content (Dry basis) 7.5% ~ 8.5% 8.00% ICP-OES
Heavy Metals ≤ 10 ppm Complies USP <231>
- Lead (Pb) ≤ 1.0 ppm 0.15 ppm ICP-MS
- Arsenic (As) ≤ 1.0 ppm 0.08 ppm ICP-MS
- Mercury (Hg) ≤ 0.1 ppm Negative ICP-MS
- Cadmium (Cd) ≤ 0.5 ppm 0.02 ppm ICP-MS
Total Plate Count ≤ 1,000 cfu/g 240 cfu/g USP <61>
Yeast & Mold ≤ 100 cfu/g 25 cfu/g USP <61>
E. Coli Negative Negative USP <62>
Salmonella Negative Negative USP <62>
Staphylococcus aureus Negative Negative USP <62>

 

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Market Trends

 

The global market trend of L-5 Methyltetrahydrofolate Calcium Salt is also getting its momentum going; the global move toward bioactive, clean-label, and naturally derived nutritional ingredients in the food and beverage and nutraceutical industry is seeing the trend gain traction. An active form folate ingredient, its formulation efficiency, stability, and compatibility with premixes, capsules, tablets, and fortified systems without needing further conversion processes are contributing to its increasing popularity with manufacturers. The trend of consumers wanting to know what is in their food is continuing, which means that products are increasingly being developed with more bio-identical and recognizable nutrients. Meanwhile, new trends such as functional foods and beverages, the concept of personalised nutrition, and new applications are expanding the application areas and further enhancing the long-term market prospects. The introduction of new production techniques, including fermentation, purification, and crystallization, has also made it more consistent and reliable in terms of supply, thus making it more readily available for large-scale industrial applications. Overall, the market is clearly heading towards natural positioning, formulation efficiency, and premium ingredient adoption throughout the global nutrition supply chain.

 

Features

 

It has a stable salt structure, high chemical purity, and a well-defined crystalline form, and could be used in a controlled industrial formulation environment. It is the calcium salt of L-5-methyltetrahydrofolate, which is more stable in handling than the free acid form, especially during standard processing practices such as blending, compression, and encapsulation. The powder usually has good flowability and dispersibility, facilitating uniform mixing for multipurpose applications and good batch distribution for formulators in premix and dry blend applications. It has a tendency to be sensitive to environmental factors like moisture, heat, and oxidation, so it is often provided to customers with specified limits of performance and packaged under controlled conditions to ensure quality integrity. The calcium counterion is responsible for increased structural stability, decreased degradation during storage and transport, and improved compatibility with a variety of excipients in food and nutraceutical formulations. L-5-Methyltetrahydrofolate Calcium also has excellent solubility properties in water-based formulation systems and can be easily incorporated into beverage and liquid premix formulations. The uniform size distribution and the standardized purity profile also facilitate the correct dosing in industrial production, and therefore, it can be used as a functional and technically sound ingredient in today's formulation design.

 

L-5-Methyltetrahydrofolate-Calcium-Powder-Benefits

 

Benefits

 

1. Formulation flexibility

5-MTHF Powder can be used in various formats such as dry blends, premixes, capsules, tablets, and liquid systems, which offer the flexibility for manufacturers to use it in a variety of production lines, with minimal changes.

2. Improved processing efficiency

The controlled particle characteristics and stable salt form also allow for better formulation control, making it easier for manufacturers to get the same particle size and consistent mixing and dosing in large-scale production.

3. Enhanced ingredient compatibility

Compounds well with standard excipients, vitamins, and functional ingredients; is not likely to cause interaction problems in standard manufacturing conditions, useful in the formulation of multi-nutrient formulations.

4. Supply chain standardization

Usually manufactured with defined assay and impurity limits in accordance with strict quality specifications to ensure the buyers have raw material with strict consistency and production planning.

5. Storage and handling convenience

The calcium complexed structure is more physically robust and easier to handle than other less stable forms of folate in the industries where it is stored, transported, and pre-processed.

6. Product development support

Supplies a consistent and trustworthy platform of active ingredients to formulators for creating differentiated nutritional combinations that present new opportunities and possibilities for clean-label and fortified products, which are not complicated by formulation.

 

Factory

 

factory

 

Certificate

 

Certificate

 

Exhibition 

 

Exhibition

 

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