L-5-MTHF Calcium Powder

L-5-MTHF Calcium Powder

Product Name: L-5 Methyltetrahydrofolate Calcium Powder / Calcium L-5-MTHF Powder
CAS No.: 151533-22-1
Purity: 99% L-5-MTHF Calcium (HPLC)
Appearance: Light Yellow to Yellow Fine Powder
Grade: Food Grade / Supplement Grade / Pharmaceutical Grade
Certificates: GMP, ISO, HACCP, Kosher, Halal, FDA
MOQ: 1kg for Sample Order / Bulk Order Available
OEM & ODM Service: Capsules, Tablets, Sachets Available
Packaging: 1kg Aluminum Foil Bag / 25kg Drum / Customized Packaging
Documents: COA, MSDS, TDS Available
Sample: Free Sample Available
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Description
Technical Parameters

What is L-5-MTHF Calcium Powder?

 

L-5-MTHF Calcium Powder is the calcium salt form of L-5-methyltetrahydrofolate (Folate), which is typically used in the formulation of food, beverage, and nutraceutical products on an industrial scale. It is designed to be utilised as an active source of folate that can be easily added to multi-ingredient systems and, therefore, is appropriate for ingredient supply chains with consistent quality and efficient processing. It is normally made by controlled synthesis and crystallization to have a consistent chemical identity, particle morphology, and assay. The calcium salt structure not only provides solid-state stability but also enhances the processing properties during downstream processing, including blending, pre-mixing, and dry granulation. This is of special importance to manufacturers that need reliable processing in a high-volume production line. Furthermore, its standardized specification profile helps to ensure uniformity throughout each batch, a key consideration for contract manufacturers and product developers of branded products dealing with global supply chains. It is commonly used as a functional folate ingredient in food systems, beverages, and nutrition premixes in applications. It works well in single-component as well as multi-component matrix systems, providing formulation teams with flexibility in product architecture design.

 

L-5-MTHF-Calcium-Powder

 

COA

 

Item Specification Result
Storage Condition Cool, dry place, protected from light and moisture Conforms
Appearance White to off-white fine powder Conforms
Odor Odorless Conforms
Solubility Freely soluble in water Conforms
Identification HPLC matches reference standard Conforms
L-5-MTHF Calcium Assay ≥ 95.0% 97.20%
Active Folate Content ≥ 95.0% of labeled value 99.00%
Particle Size (D90) ≤ 100 μm 85 μm
Loss on Drying ≤ 5.0% 2.10%
Bulk Density 0.30 – 0.60 g/mL 0.45 g/mL
pH (1% solution) 6.5 – 8.5 7.2
Heavy Metals ≤ 10 ppm < 5 ppm
Lead (Pb)
Arsenic (As) ≤ 1 ppm < 0.5 ppm
Mercury (Hg) ≤ 0.1 ppm Not detected
Residual Solvents Meets USP / ICH limits Conforms
Total Plate Count ≤ 1,000 CFU/g < 100 CFU/g
Yeast & Mold ≤ 100 CFU/g < 10 CFU/g

 

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Industry Background

 

The global nutritional ingredient market has been constantly evolving, and L-5-Methyltetrahydrofolate Calcium Powder has its origins in the increased demand for more bioactive, formulation-ready, and industry-stabilised forms of folic acid in the global market. Manufacturing systems for food, beverages, and nutraceuticals have become more complex, while the introduction of nutrients in complex formulations has sparked an interest in their suppliers to develop new forms that can be easily incorporated with better nutrient consistency and processing reliability into the complex manufacturing workflow. In this development trend, ingredients based on L-5-methyltetrahydrofolate have become significant advanced folates that fulfil today's formulation demands. The calcium salt version was developed to overcome some important industry issues like physical stability, handling efficiency, and compatibility in large-scale manufacturing, which are more suitable for global industrial supply chains where the raw materials are required to be standardized with consistent performance. Concurrently, the growth of categories of functional foods, fortified beverage systems, and multi-ingredient premix applications has had a profound impact on the shape of the demand for vitamin inputs. The availability of active folate forms has become more common in industrial applications as consumers are becoming more interested in healthful foods and products that can be promoted in clean label terms, have fewer components and easier formulation, and are produced with less energy.

 

Development Process

 

L-5 Methyltetrahydrofolate Calcium Salt has been developed based on innovations in folate chemistry and the advancement of ingredients in the industry. Early folate forms were either chemically stable but inactive in order to provide basic storage and process usability or were chemically active but had to be converted at the time of their use in formulation, which resulted in decreased production efficiency. As nutritional science advanced, the direction of development gradually turned to forms of folate that were more active to become the form that can be easily used in manufacturing systems, L-5-methyltetrahydrofolate. In the field of food, beverage, and nutritional sciences, optimization was directed to ensure the accuracy of synthesis, ensure consistency of structure, and control the purification process for industrial supply on a scale that meets market needs. Technical issues, including moisture sensitivity, environmental exposure, and powder handling behavior, continued to be an important factor when using the product. Controlled crystallization and ion stabilization to improve stability, flowability, and processing performance without changing the active structure, with the calcium salt form. Subsequent development of particle engineering and multi-stage purification led to an improvement in the uniformity of the production batch and production reliability. Consistent specifications were obtained by implementing standardized quality control systems for large-scale manufacturing. Modern precision synthesis and controlled crystallization technologies have brought the ingredient to a stage of maturity, allowing it to be used in the stable integration of the global system of food, beverage, and nutrition formulation.

 

L-5-MTHF-Calcium-Powder-application

 

Application

 

1. Food fortification industry

Functional folate input is used in the manufacturing of fortified food products, where manufacturers use it to enrich the nutrient system and design the product formula.

2. Beverage manufacturing sector

Stable dispersion and compatibility in beverage formulation (water-based or ready to mix) through the application of beverage premix and liquid enrichment systems.

3. Dietary supplement manufacturing

Used in capsule, tablet, and powder blend manufacturing as a raw material used in multi-ingredient nutritional product formulations in industrial production lines.

4. Premix and blending industry

Integrated in vitamin premixes and compound ingredient systems, allowing contract manufacturers to reliably provide exact dosing and nutrients uniformity from batch to batch, across large quantities.

5. Functional food ingredient supply chain

Structured and standardized raw material inputs are used by ingredient distributors and B2B suppliers that are part of customized formulation solutions for branded food manufacturers.

6. Contract manufacturing (OEM/ODM) sector

L-5 Methyltetrahydrofolate Calcium is used extensively in an outsourced production model for product consistency and quality of ingredients, processing stability, and a range of different formats and scalable production.

 

Production Process

 

PRODUCTION-PROCESS

 

Certificate

 

Certificate

 

Exhibition 

 

Exhibition

 

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