What is Paeoniflorin Extract?
Paeoniflorin Extract is a standardized botanical extract from the roots of Paeonia lactiflora, containing the primary marker compound paeoniflorin, as the concentration of the extract has been standardized for the extraction to be a controlled system. It is generally made using a controlled extraction with solvents and purification, concentration, and drying process with the aim of achieving the consistency of chemical composition and the correct specification for its use in the industry. It is located within ingredient supply chains where ingredient standardization, ingredient traceability, or repeatable performance is a must-have requirement, as it is used for formulation development in cosmetic, personal care, and botanical ingredient manufacturing. The composition profile is more clearly defined than crude plant materials, which enables the formulator to predictably use the input parameters of his multi-ingredient systems or standardized product lines. It is often delivered in powdered form and has controlled levels of assay, allowing for accurate dosage calculations and easy incorporation into production processes. A distinguishing feature of the extract is its plant source, providing glycosides, along with being compatible with a range of formulation matrices, including water-based and blended formulations employed in cutting-edge industrial manufacturing.

COA
| Item | Specification | Method | Result |
| Product Name | Paeoniflorin Extract Powder | Internal Specification | Complies |
| Botanical Source | Paeonia lactiflora Pall. Root | Botanical Identification | Complies |
| Active Ingredient | Paeoniflorin | HPLC | Complies |
| Assay | ≥40.0% | HPLC | 40.58% |
| Appearance | Light Brown Fine Powder | Visual | Complies |
| Color | Light Brown | Visual | Complies |
| Odor & Taste | Characteristic | Organoleptic | Complies |
| Particle Size | 95% Pass 80 Mesh | USP <786> | Complies |
| Loss on Drying | ≤5.0% | USP <731> | 2.74% |
| Ash Content | ≤5.0% | USP <281> | 2.18% |
| Bulk Density | 0.40–0.65 g/mL | USP | 0.52 g/mL |
| Tap Density | 0.55–0.85 g/mL | USP | 0.69 g/mL |
| Extract Solvent | Ethanol & Purified Water | Internal Method | Complies |
| Heavy Metals | ≤10 ppm | ICP-MS | Complies |
| Lead (Pb) | ≤2.0 ppm | ICP-MS | Complies |
| Arsenic (As) | ≤1.0 ppm | ICP-MS | Complies |
| Cadmium (Cd) | ≤1.0 ppm | ICP-MS | Complies |
| Mercury (Hg) | ≤0.1 ppm | ICP-MS | Complies |
| Total Plate Count | ≤10,000 CFU/g | USP <2021> | Complies |
| Yeast & Mold | ≤100 CFU/g | USP <2021> | Complies |
| Escherichia coli | Negative/10 g | USP <2022> | Negative |
| Salmonella | Negative/25 g | USP <2022> | Negative |
| Storage | Store in a cool, dry place, protected from light and moisture. | - | Complies |
| Shelf Life | 24 Months When Properly Stored | - | Complies |
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Industry Background
The background of the industry of Paeoniflorin Powder is associated with expanding global demand for standardized plant raw materials and the development of the botanical ingredient industry in the world. With the development of cosmetics, personal care, and botanical formulation industries, producers are moving away from using crude planting materials towards botanical extracts, which are refined and have a known chemical profile with known reproducible quality. This change is facilitated by production and the ability to be traced and interoperable with systems. It is a good example of this: the traditional plant resources are "controlled-extracted" to become ingredients that meet the specification. Increased efficiency, stability, and consistency with new and improved extraction technology, including optimized solvents, low-temperature concentration, and better drying techniques. The analytical methods, such as HPLC, can be utilized for the accurate quantification of markers and for specification control. The market view is that in the food sector, a push for plant-based, clean-label ingredients creates a demand for products that are of known origin and composition and can be documented. This pushes the suppliers to improve cultivation, traceability, and the integrated production model in order to ensure sustainability. OEM and ODM manufacturing result in additional demands for standardized botanical inputs in formulations, without the risk of formulation variation. In total, it is the evolution of a botanical resource to a controlled, standardized source that can be used worldwide and on a scale that allows formulation development.
Development History
The evolution of development history is associated with the evolution of botanical processing and the transition from the crude use of botanicals to the use of standardized ingredients on an industrial scale. The roots of Paeonia lactiflora were used as a crude medicine before chemical analysis and quantitative control. Through phytochemical research, paeoniflorin was found to be a marker compound, and extraction and standardization research was conducted. Initial extraction of solvents was of varying purity and used primarily for research purposes. With the increased demand, processes were optimised using optimised solvents, multi-stage purification, and controlled concentration, which resulted in an increase in yield and consistency. HPLC introduction facilitated a more accurate quantification and set measurable quality standards for the first time, thus changing the raw materials to specification. Further developments like low-temperature extraction, membrane separation, and precision drying further enhanced stability and scalability. Global supply chains and OEM/ODM manufacturing grew and led to greater demands for traceability and quality systems, which included controlled cultivation and screening processes. Peony Root Extract is today a standardized botanical material, with assay ranges and consistent properties for use in industry. It is universally available and produced under GMP and ISO compliant production systems to provide consistency in the supply for cosmetic and botanical formulation development, which helps to maintain supply consistency and scalability globally.

Applications
1. Cosmetic & Personal Care Industry
Paeonia Lactiflora Root Extract is occasionally used in skin care formulation systems like creams and lotions, facial serums, masks, and emulsions where the use of plant-derived ingredients is favoured for clean-label and botanical-based product concepts.
2. Nutraceutical Ingredient Manufacturing
As an agreed botanical raw material for capsule, tablet, powder blend, and sachet formulation for plant-based nutritional formulation portfolio companies.
3. Functional Beverage & Food Ingredient Sector
Used in botanical beverage premixes, powdered drink systems, and specialty ingredients blends where the plant extract components need to have a constant specification.
4. OEM & ODM Contract Manufacturing
Often used by contract manufacturers when they need to have consistent and reproducible assay values for their botanical ingredients, source documentation, and a large bulk size supply.
5. Plant Extract Research & Development
Laboratories and industrial R&D laboratories that are working on botanical ingredient innovation use this for phytochemical analysis, formulation screening, and ingredient compatibility testing.
6. Natural Raw Material Trading Industry
It is distributed internationally as a specification extract for importers, wholesalers, and raw material procurement companies in the form of an extract.
7. Herbal Formulation Blending Industry
They have been incorporated into multi-botanical compound systems in which standardized extracts have to be used to ensure uniformity and consistency in the production of the compound from batch to batch.
Production Process

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