Xi'an Sentian Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of bromelain in China. We are committed to providing high quality customized service and OEM&ODM private label service for global clients. Please feel free to buy bulk bromelain in stock here from our factory. Also, free sample is available.
Bromelain is a proteolytic enzyme mixture derived from the stem and fruit of the pineapple plant (Ananas comosus). Primarily used as a dietary supplement for reducing inflammation, swelling, and aiding digestion, it is often used for arthritis, muscle soreness, and sinusitis. It acts by breaking down proteins and is generally considered safe.
Anti-inflammatory: Effective for reducing nasal inflammation, osteoarthritis pain, and muscle soreness.
Digestive Aid: Helps break down protein, reducing bloating and aiding individuals with digestive issues or pancreatic insufficiency.
Wound Care: Used topically to remove dead skin from burns.
Post-Surgery: Used to treat swelling and pain after surgery.
Everything You Need to Know
What is the bromelain enzyme used for?
Does bromelain reduce inflammation?
In addition, bromelain exhibits anti-inflammatory properties that may help alleviate digestive discomfort associated with inflammation in the gastrointestinal tract. By modulating inflammatory mediators and reducing mucosal inflammation, bromelain may mitigate symptoms such as bloating, gas, and abdominal pain.
Can I take bromelain with collagen?
Yes, bromelain and collagen can be used together and may have some potential benefits. Bromelain is an enzyme derived from the pineapple plant and is known for its anti-inflammatory properties, while collagen is a protein important for skin health, joint function, and strengthening connective tissues.
Who cannot take bromelain?
Use cautiously if you are allergic to pineapple, latex, ragweed, Echinacea, chrysanthemums, marigolds, daisies, wheat, celery, papain, carrot, fennel, cypress pollen, grass pollen, or other plants. Surgery: Bromelain might increase the risk of bleeding during and after surgery.
Main Applications:
Meat tenderizing and other uses
Along with papain, bromelain is one of the most popular proteases to use for meat tenderizing. Bromelain is sold in a powdered form, which is combined with a marinade, or directly sprinkled on the uncooked meat.
Cooked or canned pineapple does not have a tenderizing effect, as the enzymes are heat-labile and denatured in the cooking process. Some prepared meat products, such as meatballs and commercially available marinades, include pineapple and/or pineapple-derived ingredients.
Although the quantity of bromelain in a typical serving of pineapple fruit is probably fairly minimal, specific extraction can yield sufficient quantities for domestic and industrial processing, including uses in baking, anti-browning of cut fruit, textiles and cosmetics manufacturing.
Potential medical uses
A concentrate of proteolytic enzymes enriched in bromelain is approved in Europe for the debridement (removal of dead tissue) of severe burn wounds under the trade name NexoBrid.
Bromelain has not been scientifically proven to be effective in treating any other diseases, and the U.S. Food and Drug Administration has not approved it for the treatment of any disorder. In the United States, the passage of the Dietary Supplement Health and Education Act (DSHEA, 1994) allows the sale of bromelain-containing dietary supplements even though efficacy has not been confirmed.
While there have been studies which positively correlated the use of bromelain with reduction of symptom severity in osteoarthritis,[9][10] "[t]he majority of the studies have methodological issues that make it difficult to draw definite conclusions", as none definitively established efficacy, recommended dosage, long term safety, or adverse interaction with other medications.
Systemic enzyme therapy (consisting of combinations of proteolytic enzymes such as bromelain, trypsin, chymotrypsin, and papain) has been investigated in Europe to evaluate the efficacy in breast, colorectal, and plasmacytoma cancer patients.
Bromelain may be effective as an adjunct therapy in relieving symptoms of acute rhinosinusitis in patients not treated with antibiotics.
Bromelain is also claimed as a tooth plaque removal enhancer in toothpastes.
ANALYTICAL RESULTS
| Test Item | Specification | Result | Method | Conclusion |
|---|---|---|---|---|
| Appearance | Off-white to light yellow powder | Light yellow powder | Visual | Conforms |
| Odor | Characteristic | Complies | Organoleptic | Conforms |
| Identification | Positive | Positive | Enzymatic activity / Gelatin digestion, House Method | Conforms |
| Bromelain Activity | ≥ 2,400 GDU/g | 2,685 GDU/g | Gelatin Digestion Unit (GDU) Method / USP-aligned | Conforms |
| Loss on Drying | ≤ 7.0% | 4.76% | USP <731> | Conforms |
| Ash | ≤ 5.0% | 2.14% | USP <281> | Conforms |
| pH (1% solution) | 5.0 – 7.5 | 6.35 | USP <791> | Conforms |
| Lead (Pb) | ≤ 1.0 ppm | 0.05 ppm | ICP-MS | Conforms |
| Cadmium (Cd) | ≤ 0.5 ppm | < 0.05 ppm | ICP-MS | Conforms |
| Arsenic (As) | ≤ 1.0 ppm | 0.11 ppm | ICP-MS | Conforms |
| Mercury (Hg) | ≤ 0.1 ppm | < 0.01 ppm | ICP-MS | Conforms |
| Total Plate Count | ≤ 1,000 CFU/g | 150 CFU/g | USP <61> | Conforms |
| Yeast & Mold | ≤ 100 CFU/g | < 10 CFU/g | USP <61> | Conforms |
| Coliforms | ≤ 10 CFU/g | < 10 CFU/g | USP <62> | Conforms |
| Escherichia coli | Negative / g | Negative | USP <62> | Conforms |
| Salmonella | Negative / 25 g | Negative | USP <62> | Conforms |
| Staphylococcus aureus | Negative / g | Negative | USP <62> | Conforms |
| Residual Ethanol | ≤ 5,000 ppm | 210 ppm | GC-HS / ICH Q3C | Conforms |
| Residual Hexane | ≤ 290 ppm | < 10 ppm | GC-HS / ICH Q3C | Conforms |
Production Process
