Nattokinase is an enzyme that comes from a Japanese food called natto. Natto is made from boiled soybeans that have been fermented with a type of bacteria. Nattokinase may thin the blood and help break up blood clots.
Nattokinase is an enzyme that comes from a Japanese food called natto. Natto is made from boiled soybeans that have been fermented with a type of bacteria.
Nattokinase may thin the blood and help break up blood clots. This might protect against heart disease and conditions caused by blood clots such as stroke, heart attack, and others.
Everything You Need to Know
Is it safe to take nattokinase every day?
Does nattokinase clean your arteries?
After 12 months of NK consumption, both the size of CCA-IMT and the size of the carotid artery plaque decreased significantly (from 1.33 to 1.04mm on average, P < 0.001). The size of the plaque decreased by up to 36%, suggesting that NK is very effective in improving/reducing carotid atherosclerosis
What are the negative side effects of nattokinase?
Bleeding disorders: Nattokinase seems to act like a blood thinner and might make bleeding disorders worse. Use with caution. Surgery: Nattokinase might increase the chance of bleeding during or after surgery. It might also make blood pressure difficult to control during surgery.
Can nattokinase affect the liver?
The results showed that NK improved liver functions, impaired oxidative status, the cholinergic deficits, and minified the misfolded proteins aggregates.
Main Applications:
prevention of cardiovascular diseases
improves blood flow. Nattokinase is often referred to as a 'natural blood thinner'. This effect is due to its ability to break down fibrin, a protein that forms during blood clotting. This enables nattokinase not only to counteract the formation of blood clots, but also to dissolve smaller blood clots that have already formed – an important protective mechanism against cardiovascular diseases caused by blood clots (e.g. heart attacks, strokes).
lowers blood pressure. High blood pressure is usually the first sign of cardiovascular disease. In the long term, this vascular hyperpressure can lead to a vicious circle, as it can also cause vascular damage.
Chronic inflammation is the underlying cause of a variety of diseases. This also applies, among other things, to arteriosclerosis (= vascular calcification), in which chronic inflammatory processes occur in the vessel walls. Based on this background, researchers wondered whether and how Nattokinase can influence inflammatory processes. It was shown both in cell experiments in the laboratory and in a living model (in vivo – in a living organism) that the enzyme can inhibit certain inflammatory processes and regulate an overactivation of the immune system (the macropages).
Nattokinase is generally considered to be a natural substance with few side effects. However, people who are already taking blood-thinning medication should not use nattokinase without medical advice and supervision, as this can increase the effect of the blood-thinning medication and cause unwanted side effects.
ANALYTICAL RESULTS
| Test Item | Specification | Result | Method | Conclusion |
|---|---|---|---|---|
| Appearance | Off-white to light yellow powder | Off-white powder | Visual | Conforms |
| Odor | Characteristic fermentation odor | Complies | Organoleptic | Conforms |
| Identification | Positive | Positive | Enzymatic profile / House Method | Conforms |
| Nattokinase Activity | ≥ 20,000 FU/g | 21,350 FU/g | Fibrin Plate Method / House Method | Conforms |
| Loss on Drying | ≤ 7.0% | 4.28% | USP <731> / 105°C | Conforms |
| Ash | ≤ 5.0% | 1.84% | USP <281> | Conforms |
| pH (1% solution) | 5.5 – 7.5 | 6.42 | USP <791> | Conforms |
| Bulk Density | 0.35 – 0.65 g/mL | 0.48 g/mL | House Method | Conforms |
| Lead (Pb) | ≤ 1.0 ppm | 0.08 ppm | ICP-MS | Conforms |
| Cadmium (Cd) | ≤ 0.5 ppm | < 0.05 ppm | ICP-MS | Conforms |
| Arsenic (As) | ≤ 1.0 ppm | 0.12 ppm | ICP-MS | Conforms |
| Mercury (Hg) | ≤ 0.1 ppm | < 0.01 ppm | ICP-MS | Conforms |
| Total Plate Count | ≤ 1,000 CFU/g | 120 CFU/g | USP <61> | Conforms |
| Yeast & Mold | ≤ 100 CFU/g | < 10 CFU/g | USP <61> | Conforms |
| Coliforms | ≤ 10 CFU/g | < 10 CFU/g | USP <62> | Conforms |
| Escherichia coli | Negative / g | Negative | USP <62> | Conforms |
| Salmonella | Negative / 25 g | Negative | USP <62> | Conforms |
| Staphylococcus aureus | Negative / g | Negative | USP <62> | Conforms |
| Residual Ethanol | ≤ 5,000 ppm | 186 ppm | GC-HS / ICH Q3C | Conforms |
| Residual Hexane | ≤ 290 ppm | < 10 ppm | GC-HS / ICH Q3C | Conforms |
Production Process
